克罗米酚对男性低促性腺素持续性减退症有效

芝加哥（路透社身体健康旧版）1年末四日报道：据刊载在12年末年末出旧版的《生育与不育》杂志的一项年度报告认为克罗米胺对大部分高促性腺可抑制性功能减退的成年病症十分困难。来自伯明翰阿拉巴马所大学的该年度报告的第一作者Scott J. Whitten博士在放弃路透通讯社访谈时说：“细菌性或获得性HH病症在放弃妨碍性极大和更为昂贵的疗程（例如针头促性腺激可抑制类）前透过4个年末的克罗米胺实验性疗程是十分困难的。”Whitten博士和同事研究成果了克罗米胺对10名HH成年病症（HH是导致成年不育的少见因可抑制）是否有效。年度报告称克罗米胺疗程1年后，4名卡尔曼(氏)病症病症中只有一名病症的**pH减小而全轴突功能减退症病症的**缺失副作用均不能得到改善。比如说，该年度报告认为3名成年发病的细菌性HH成年病症经过3个年末克罗米胺的疗程**pH有了明显减小。目前为止该组病症已有两名直至了身体健康。Whitten博士说：“除非对克罗米胺疗程不能底物，我们不必因为副作用停止对病症使用该药剂。”最后作者总结说：“因为条件有限，对HH病症促性腺激可抑制类药剂和克罗米胺的随机研究成果不足以透过，然而利用多系列的严格选择标准对病症透过分级可能帮助进一步验证克罗米胺直至成年高身体健康的必要性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

主笔：蓝色幻想

主笔： 张靖